Evidence and research
Landmark Papers
Important neurosurgical publications organized by topic.
40 publications
Topic Trauma
- BOOST II Trial Brain Tissue Oxygen Monitoring and Management in Severe Traumatic Brain Injury (BOOST-II)
- CRASH-1 Trial Study of the efficacy of methylprednisolone in patients with traumatic brain injury.
- CRASH 2 Trial Study on the efficacy of tranexamic acid in patients with traumatic brain injury.
- CRASH 3 Trial Study on the efficacy of tranexamic acid in patients with traumatic brain injury.
- DECRA Trial Study of decompressive craniectomy in patients with traumatic brain injury.
- EUROTHERM3235 Hypothermia in patients with elevated intracranial pressure
- Rescue ICP Trial Study of hemicraniectomy in patients with traumatic brain injury.
Topic Spine
- CAFE Trial Cancer Patient Fracture Evaluation
- NECK Trial ACDF vs ACD vs ACDA
- NORCAT Trial Norwegian Cervical Arthroplasty Trial
- NORDSTEN Trial Decompression with or without fusion in degenerative lumbar spondylolisthesis
- SLIP Trial Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis
- SPORT Trial - Lumbar Disk Herniations SPORT Trial Comparing Surgical and Nonoperative Treatment of Lumbar Disk Herniations
- SPORT Trial - Spinal Stenosis Without Spondylolisthesis Conservative versus surgical treatment for spinal stenosis without spondylolisthesis.
- SPORT Trial - Spinal stenosis with spondylolisthesis Conservative versus surgical treatment for spinal stenosis without spondylolisthesis.
Topic Carotid stenosis
Topic Malignant MCA infarction
- DECIMAL Trial Study of hemicraniectomy for malignant MCA infarction.
- DESTINY II Trial Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery II (DESTINY II)
- DESTINY Trial Study on hemicraniectomy for malignant middle cerebral artery infarction.
- HAMLET Trial Study of hemicraniectomy for malignant middle cerebral artery infarction.
- HeADDFIRST Trial Study of decompressive hemicraniectomy in malignant MCA infarctions.
Topic Arteriovenous malformations
Topic Intracerebral hemorrhage
- ATACH-2 Trial Study of intensive blood pressure reduction in acute intracerebral hemorrhage.
- ENRICH Trial Conservative versus minimally invasive surgical treatment of intracerebral hemorrhages
- MIND Trial 2025 Randomized controlled trial n = 236 MIND found no significant benefit of minimally invasive hematoma evacuation over medical management alone for disability and death at 180 days or for 30-day mortality.
- MISTIE III Trial Study of the efficacy of minimally invasive hematoma evacuation followed by thrombolysis.
- STICH II Trial Study on the efficacy of surgical treatment for intracerebral hemorrhage.
- STICH I Trial Study on the efficacy of surgical treatment of intracerebral hemorrhage.
- SWITCH Trial Conservative treatment versus decompressive hemicraniectomy for deep-seated intracerebral hemorrhages.
Topic Subarachnoid hemorrhage
Topic Glioblastoma
Topic Surgical technique
- Anterior cervical discectomy (ACD) 1958 Technical historical paper Cloward’s 1958 paper described anterior cervical discectomy followed by vertebral-body fusion in detail, establishing a key technical foundation of modern anterior cervical spine surgery.
- Cervical lateral mass screw fixation Technique for cervical lateral mass stabilization according to An et al.
Topic Study metrics
Topic Chronic subdural hematoma
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