Combined radiochemotherapy with Temozolomide for glioblastoma

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The study by Roger Stupp et al.1, published in NEJM in 2005, is considered the basis of current treatment for glioblastoma. It demonstrated for the first time that combined radiochemotherapy with Temozolomide provides a significant and clinically relevant survival benefit in the treatment of glioblastoma.

Stupp survival in glioblastoma
Survival time comparing radiotherapy alone with combined radiotherapy and Temozolomid (Stupp regimen). Figure adapted from Stupp et al. 2005.

References

    1. Stupp, Roger, et al. "Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma." New England journal of medicine 352.10 (2005): 987-996. ↩ ↩

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    • Text changed: “The 2005 study by Roger Stupp et al.[^1], published in the NEJM, is considered the basis of current treatment for [glioblastoma](\/neurochirurgische-krankheitsbilder\/glioblastom). It demonstrated for the first time that combined radiochemotherapy with Temozolomide provides a significant and clinically relevant survival benefit in the treatment of glioblastoma.”“The study by Roger Stupp et al.[^1], published in NEJM in 2005, is considered the basis of current treatment for [glioblastoma](\/neurochirurgische-krankheitsbilder\/glioblastom). It demonstrated for the first time that combined radiochemotherapy with Temozolomide provides a significant and clinically relevant survival benefit in the treatment of glioblastoma.”

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