Name: ISUIA Trial
Published: 2022-11-05T00:00:00+00:00

The ISUIA Trial was published in The Lancet in 2003 and investigated the management of unruptured intracranial aneurysms in a total of 4060 patients enrolled in the study from 61 centers¹.

Cumulative 5-year rupture risk

ISUIA rupture risk — Group 1 = Without a history of subarachnoid hemorrhage. Group 2 = With a history of subarachnoid hemorrhage. Figure adapted from the original publication of the ISUIA study.

Interpretation by the study authors

Many factors are involved in management of patients with unruptured intracranial aneurysms. Site, size, and group specific risks of the natural history should be compared with site, size, and age-specific risks of repair for each patient.²

References

Wiebers, David O., and International Study of Unruptured Intracranial Aneurysms Investigators. "Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment." The Lancet 362.9378 (2003): 103-110. ↩ ↩ ↩ ↩