HeADDFIRST Trial

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The HeADDFIRST Trial is a pilot study on decompressive hemicraniectomy in malignant space-occupying infarctions and was published in 2014. However, patient enrollment had already taken place in 2000–20021.

Authors' conclusion

HeADDFIRST randomization criteria effectively distinguished low from high
risk of death from LSCHI. Lower mortality in the MTO group than in other published trials suggests a possible benefit to standardizing medical management. These results can inform the interpretation of recently completed European trials regarding patient selection and medical
management.

References

    1. Frank, Jeffrey I., et al. "Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial." Stroke 45.3 (2014): 781-787. ↩ ↩

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    • Text changed: “The HeADDFIRST Trial is a pilot study on [decompressive hemicraniectomy](\/lexikon\/dekompressive-hemikraniektomie) for malignant space-occupying infarctions and was published in 2014. However, patient enrollment had already taken place in 2000-2002[^1].”“The HeADDFIRST Trial is a pilot study on [decompressive hemicraniectomy](\/lexikon\/dekompressive-hemikraniektomie) in malignant space-occupying infarctions and was published in 2014. However, patient enrollment had already taken place in 2000–2002[^1].”

    Article created on · Alaric Steinmetz

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