Tuberculum sellae meningioma

Synonyms
Tuberculum sellae meningiomas, TSM
ICD-10
D32.-
ICD-11
2A01.0

Tuberculum sellae meningiomas are Meningiomas that arise from the Tuberculum sellae.

Historical background

The first description of a Tuberculum sellae meningioma was provided by Stewart J. in 1899 in an autopsy report[^2].

Epidemiology

Tuberculum sellae meningiomas account for approximately 5-10 % of all intracranial meningiomas [^3].

Location

By definition, the anterior border of the Sulcus chiasmatis (Limbus sphenoidale) is the boundary between the anterior and middle cranial fossa. Therefore, Tuberculum sellae meningiomas are located in the middle cranial fossa. Planum sphenoidale- and olfactory meningiomas, in contrast, arise from the anterior cranial fossa.

Symptoms

The most common symptom of a symptomatic Tuberculum sellae meningioma is progressive, painless visual loss, which may be unilateral or bilateral, with homonymous or bitemporal hemianopia. Patients with larger Tuberculum sellae meningiomas may also develop endocrine dysfunction due to compression of the Pituitary gland or the Pituitary stalk. Less common symptoms include headache or epileptic seizures[^1].

Imaging

The gold standard for imaging Tuberculum sellae meningiomas is MRI imaging.

Tuberculum sellae meningioma MRI
Sagittal contrast-enhanced T1 MRI image of a tuberculum sellae meningioma.
Tuberculum sellae meningioma MRI
Sagittal and axial MRI (contrast-enhanced T1-weighted sequence) of a tuberculum sellae meningioma.

Surgical treatment

Tuberculum sellae meningiomas can be accessed and resected via different surgical approaches.

Unilateral subfrontal approach

A unilateral subfrontal approach is suitable for particularly large Tuberculum sellae meningiomas, as this approach provides optimal intraoperative visualization [^4].

Subfrontal approach
Subfrontal approach for resection of tuberculum sellae meningiomas. Figure adapted from Li, Yang, et al. Individualized surgical treatment of giant tuberculum sellae meningioma Unilateral subfrontal approach vs. endoscopic transsphenoidal approach. Frontiers in Surgery 9 (2022) 990646.

Endoscopic endonasal approach

Another frequently used approach is the endoscopic endonasal approach [^4].

Endoscopic endonasal approach
Endoscopic endonasal approach for resection of tuberculum sellae meningiomas. Figure adapted from Li, Yang, et al. Individualized surgical treatment of giant tuberculum sellae meningioma Unilateral subfrontal approach vs. endoscopic transsphenoidal approach. Frontiers in Surgery 9 (2022) 990646.

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