Carotid-Cavernous Fistula (CC Fistula)

Last edit by Alaric Steinmetz on

Synonyms: CC-Fistel, CCF

A carotid-cavernous fistula is a direct shunt connection between the Internal carotid artery, its meningeal branches, or branches of the External carotid artery.

Etiology

CC fistulas can occur spontaneously, iatrogenically, or traumatically. A carotid-cavernous fistula occurs in approximately 0.2% of all patients with a Traumatic brain injury[^1].

Symptoms

The clinical symptoms of CC fistulas vary depending on their severity but may include the following[^2]:

  • Subjective bruit

  • Diplopia

  • Tearing and red eye

  • Foreign body sensation in the eye

  • Blurred vision

  • Headache

Eye with CC fistula
Episcleral and conjunctival injection in a patient with arterialized vessels due to a left-sided CC fistula.

Imaging

The gold standard for diagnosing CC fistulas is Digital subtraction angiography.

DSA of a carotid-cavernous fistula
Digital subtraction angiography of a carotid-cavernous fistula. Left: Angiography of the left ICA showing contrast extravasation into the cavernous sinus. Center: Angiography of the external carotid artery showing contrast extravasation into the cavernous sinus. Right: Center image without bone subtraction for anatomical orientation. The carotid-cavernous fistula shown is a Barrow type D fistula.

Classification

CC fistulas can be classified according to the Barrow classification[^3].

Prognosis

More than 80% of patients treated endovascularly achieve complete recovery[^4] [^5]. Approximately 40% of patients experience a transient worsening of symptoms after the intervention, which improves again over time[^6]. The symptoms of Chemosis and Proptosis usually resolve within hours to days, whereas deficits involving the Cranial nerves normally require several weeks to recover. Visual recovery is variable and depends on the duration, severity, and exact cause[^4].

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