Posterior Reversible Encephalopathy Syndrome (PRES)

ICD-10
I67.83
ICD-11
8B22.Y

Posterior reversible encephalopathy syndrome (PRES) is an acute form of Encephalopathy.

Clinical presentation

Posterior reversible encephalopathy syndrome (PRES) presents clinically with headache, visual disturbances, seizures, and changes in personality or impaired consciousness. In contrast to hypertensive encephalopathy, PRES can also manifest without a clinically significant increase in blood pressure.

Imaging

MRI imaging typically shows bilateral changes in the white matter, which are interpreted as vasogenic edema. Diffusion restriction is generally not seen on MRI [^1].

PRES syndrome MRI
Axial T2 sequence of a brain MRI in a patient with posterior reversible encephalopathy syndrome (PRES).

Treatment

Treatment consists of eliminating the underlying causes, combined with antihypertensive and anticonvulsant therapy. Because untreated PRES can lead to severe neurological deficits, Status epilepticus, and even death, intensive care treatment is necessary in many cases.

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