Astroblastoma

Synonyms
Astroblastoma
ICD-10
C71.9
ICD-11
XH1DC5, 2A00.4

Astroblastoma is an extremely rare[^1] GFAP-positive glial tumor that occurs in children and young adults[^2].

Historical background

Astroblastoma was first described in 1930 by Bailey and Cushing[^5].

Epidemiology

Astroblastomas are rare brain tumors and account for approximately 0.45% to 2,% of all gliomas[^3] [^4].

Imaging

On imaging, astroblastomas frequently appear as well-demarcated tumors with solid and cystic components. Astroblastomas frequently demonstrate intratumoral cysts and a "bubbly" appearance [^6].

MRI

On MRI imaging, astroblastomas frequently appear hyperintense relative to white matter on T2 and FLAIR sequences and hypo- to isointense on T1 sequences. The tumor typically demonstrates heterogeneous contrast enhancement.

CT

On CT imaging, astroblastomas, as on MRI, demonstrate heterogeneous contrast enhancement. Calcifications are also frequently seen on CT [^6].

Histopathology

The tumor is characterized by astroblastic pseudorosettes, which are formed by tumor tissue tapering toward central blood vessels[^2].

Astroblastoma histopathology
H&E staining showing perivascular pseudorosettes in an astroblastoma. Figure adapted from Wikimedia Commons.

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