The Snake Eyes Sign is a radiological sign best visualized on the axial T2 MRI sequence of the spinal cord and was first described in 1986[^3]. It consists of bilaterally symmetric, circular to oval hyperintense foci on the T2 sequence in the anterior horn cells of the spinal cord[^2].
Etiology
The Snake Eyes sign is associated with various diseases[^2][^1]:
Ischemia of the Arteria spinalis anterior
Chronic compressive Myelopathy
Degenerative cervical myelopathy
Spinal muscular atrophy
Pathophysiology
The pathophysiology of the Snake Eyes Sign has not been fully elucidated. Histopathologically, the Snake Eyes Sign appears as a result of cystic necrosis at the junction of the gray matter[^2].
