Epidermoid cyst

Synonyms
Cholesteatom, ectodermal inclusion cyst, pearly tumor, Epidermoid cyst
ICD-10
Q07.8
ICD-11
EK70.0

Epidermoid cysts are cysts lined by squamous epithelium that contain keratin, cellular debris, and cholesterol[^3]. Unlike classic tumors, which exhibit exponential growth, epidermoid cysts, like normal skin, exhibit linear growth[^4].

Epidemiology

Epidermoid cysts account for approximately 1 % of all intracranial tumors[^2] and approximately 7 % of all Tumors in the Cerebellopontine angle. The most common age at initial diagnosis is approximately 40 years, and there is no difference in prevalence between men and women[^1].

Imaging

On MRI imaging, epidermoid cysts appear similar to Cerebrospinal fluid on T1- and T2-weighted sequences. The DWI sequence can be used to reliably distinguish them from Arachnoid cysts, as epidermoid cysts show diffusion restriction.

T1 sequence

T1 sequence with contrast enhancement

T2 sequence

DWI

Hypointense

No contrast enhancement

Hyperintense

Diffusion restriction / hyperintense

Epidermoid cyst on MRI
MRI imaging (left: T2-weighted sequence; right: contrast-enhanced T1-weighted sequence) of a histopathologically verified epidermoid cyst in the region of the left occipital bone.

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