Angiocentric glioma

Last edited and medically reviewed by Alaric Steinmetz on 09.02.2023

Synonyms

Angiocentric glioma, Monomorphes angiozentrisches Gliom, Monomorphous angiocentric glioma

Angiocentric glioma is classified as a WHO Grade I brain tumor. It is a slow-growing tumor that primarily occurs in children or young adults and is characterized by an angiocentric growth pattern. The tumor cells are monomorphic bipolar cells that show ependymal differentiation¹. Surgical resection offers the possibility of curative treatment when complete resection is achieved².

Clinical presentation

Angiocentric gliomas usually present clinically with drug-resistant epilepsy³.

Imaging

On MRI, angiocentric gliomas appear as well-circumscribed lesions that are hyperintense on FLAIR and show no contrast enhancement⁴. They are usually located very superficially in the cortex, with the frontoparietal cortex most commonly affected, followed by the temporal cortex⁵.

Histopathology

The tumor cells of an angiocentric glioma show immunoreactivity for EMA, GFAP, S-100, and vimentin, but not for neuronal antigens⁶.

References

Handbook of Neurosurgery. Greenberg M, ed. 9th Edition. Thieme; 2019. ↩ ↩ ↩ ↩ ↩ ↩
Louis DN, Ohgaki H, Wiestler OD, et al.: The 2007 WHO classification of tumours of the central nervous system. In: Acta Neuropathol. 114, Nr. 2, August 2007, S. 97–109. ↩ ↩ ↩ ↩ ↩ ↩