Isocitrate dehydrogenase (IDH) is an enzyme normally found in the human body that catalyzes the conversion of isocitrate to α-ketoglutarate in the citric acid cycle.
Clinical relevance
Mutations in the IDH gene occur in many tumor types, but not in normal cells. IDH mutations are found in 70-80 % of secondary Glioblastomas as well as in their precursor tumors, grade 2 and 3 gliomas. In primary glioblastomas, however, IDH mutations occur in only 5 % of cases[^1]. The prognosis is better in patients with an IDH mutation than in patients with IDH wild-type tumors[^1].