RANO Criteria for High-Grade Gliomas

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The RANO Working Group continuously adapts radiological criteria to measure treatment effects in various brain tumors and make them comparable under clinical trial conditions1. The following table of RANO criteria applies to high-grade gliomas

Criterion Complete Response Partial Response Stable Disease Progression
MRI T1 contrast enhancement Not detectable Reduction of ≥ 50 % Reduction < 50 % but < 25% increase Increase of more than 25 %
MRI T2/FLAIR Stable or ↓ Stable or ↓ Stable or ↓ Stable or ↑
New lesions No No No Detectable
Corticosteroids None Stable or ↓ Stable or ↓ N/A
Clinical status Stable or ↑ Stable or ↑ Stable or ↑ ↓
Required for response All criteria All criteria All criteria At least one criterion

RANO criteria for high-grade gliomas
Illustration of the RANO criteria for high-grade gliomas from the 2017 publication.

References

    1. Wen, Patrick Y., et al. "Response assessment in neuro-oncology clinical trials." Journal of Clinical Oncology 35.21 (2017): 2439. ↩ ↩

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    • Text changed: “The RANO Working Group continually adapts radiological criteria to measure treatment effects in various brain tumors and make them comparable under study conditions[^1]. The following table of RANO criteria applies to high-grade gliomas”“The RANO Working Group continuously adapts radiological criteria to measure treatment effects in various brain tumors and make them comparable under clinical trial conditions[^1]. The following table of RANO criteria applies to high-grade gliomas”
    • Text changed: “| Criterion | Complete Response | Partial Response | Stable Disease | Progression | | --------- | ----------------- | ---------------- | -------------- | ----------- | | MRI T1 contrast enhancement | Not detectable | Reduction of ≥ 50 % | Reduction < 50 % but < 25% increase | Increase of more than 25 % | | MRI T2\/FLAIR | Stable or ↓ | Stable or ↓ | Stable or ↓ | Stable or ↑ | | New lesions | No | No | No | Detectable | | Corticosteroids | None | Stable or ↓ | Stable or ↓ | N\/A | | Clinical status | Stable or ↑ | Stable or ↑ | Stable or ↑ | ↓ | | Required for response | All criteria | All criteria | All criteria | At least one criterion |”“| Criterion | Complete Response | Partial Response | Stable Disease | Progression | | --------- | ----------------- |-------------------|----------------|----------| | MRI T1 contrast enhancement | Not detectable | Reduction of ≥ 50 % | Reduction < 50 % but < 25% increase | Increase of more than 25 % | | MRI T2\/FLAIR | Stable or ↓ | Stable or ↓ | Stable or ↓ | Stable or ↑ | | New lesions | No | No | No | Detectable | | Corticosteroids | None | Stable or ↓ | Stable or ↓ | N\/A | | Clinical status | Stable or ↑ | Stable or ↑ | Stable or ↑ | ↓ | | Required for response | All criteria | All criteria | All criteria | At least one criterion |”
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