Transsphenoidal approach Last edited and medically reviewed by Alaric Steinmetz on 09.06.2022 The transsphenoidal approach is a surgical approach through the nose to the pituitary region. It is used particularly for space-occupying lesions in the sellar region1 . References Hardy J, Vezina J. Transsphenoidal neurosurgery of intracranial neoplasm. Adv Neurol. 1976;15:261-273.. ↩ ↩