Tranexamic acid (Cyklokapron)

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Tranexamic acid (trade name: Cyklokapron) prevents the breakdown of fibrin that has already formed and is administered as an adjunct to other measures in cases of acute bleeding and unexplained coagulation disorders. A large randomized study (CRASH-2)1 showed that administration of tranexamic acid reduces mortality in actively bleeding trauma patients. The administration of tranexamic acid remains controversial.

References

    1. Williams-Johnson, J. A., et al. "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial." West Indian Medical Journal 59.6 (2010): 612-624. ↩ ↩

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