Solitary fibrous tumor/hemangiopericytoma (SFT/HPC)

Last edited and medically reviewed by Alaric Steinmetz on 28.10.2022

Synonyms

SFT/HPC, Solitary fibrous tumor/hemangiopericytoma

ICD-10

D21.9

Solitary fibrous tumors and hemangiopericytomas were combined in the 2016 WHO classification and are now referred to as solitary fibrous tumor/hemangiopericytoma (SFT/HPC)¹ ². This is a mesenchymal tumor of fibroblastic type³.

Epidemiology

SFT/HPCs are rare tumors and account for approximately ~ 0.4% of all primary CNS tumors⁴.

Pathology

To confirm the diagnosis of a solitary fibrous tumor/hemangiopericytoma, immunohistochemical detection of nuclear STAT6 expression is recommended⁵.

WHO classification

Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) are classified as WHO grade 1–3 tumors⁶:

WHO grade 1: Hypocellular, collagenized tumor with a classic solitary fibrous tumor phenotype.
WHO grade 2: Denser than WHO grade 1, with fewer than 5 mitoses per 10 high-power fields (10 HPF, high-power fields).
WHO grade 3: As grade 2, but with ≥ 10 mitoses per 10 high-power fields (10 HPF, high-power fields)

References

Handbook of Neurosurgery. Greenberg M, ed. 9th Edition. New York: Thieme; 2019. ↩ ↩ ↩ ↩ ↩ ↩
Louis DN, Ohgaki H, Wiestler OD, et al. WHO classification of tumors of the central nervous system. Lyon, France 2016. ↩ ↩ ↩ ↩ ↩ ↩