The Multinodular and Vacuolating Neuronal Tumor of the Cerebrum (MVNT) is a new tumor entity that was first described in 2013 by Huse et al. in a case series1. MVNTs are stable lesions in the brain that exhibit a typical radiological pattern and are clinically associated with epileptic seizures2.
WHO Classification
According to the 2021 WHO Classification, MVNTs are classified as WHO Grade 1 tumors3.
Pathology
MVNT is a mitotically inactive multinodular neuroepithelial tumor composed of neuronal tumor cells. MVNTs show an abnormality in MAPK pathway activation. However, demonstrating such an abnormality is not essential for the diagnosis4.
Imaging
MRI of an MVNT shows clusters of multiple round or oval intra-axial nodules, which are hyperintense on T2 and FLAIR sequences5. MVNTs are usually found as juxtacortical clusters and have no mass effect or contrast enhancement6.
References
Huse, Jason T., et al. "Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure‐associated lesion." Brain Pathology 23.5 (2013): 515-524. ↩ ↩
Buffa, Geraldine Belén, et al. "Multinodular and Vacuolating neuronal tumor of the cerebrum (MVNT): a case series and review of the literature." Journal of Neuroradiology 47.3 (2020): 216-220. ↩ ↩ ↩ ↩
Rudà, Roberta, et al. "Eano-Euracan-Sno Guidelines on Circumscribed Astrocytic GLIOMAS, Glioneuronal and Neuronaltumors." Neuro-Oncology (2022). ↩ ↩ ↩ ↩ ↩ ↩