Synaptophysin is a protein found in synaptic vesicles.
Pathology
In neuropathology, a stain against synaptophysin is used to detect synaptic vesicles. Compared with chromogranin, synaptophysin staining has higher sensitivity but lower specificity[^1]. In central neurocytoma, synaptophysin staining is often positive while chromogranin staining is negative[^2].